产品货号：
Z30309
中文名称：
IGF1R抗体
英文名称：
Anti-IGF1R Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IGF1R Antibody |
| 指标别名 | CD221;IGF I receptor;IGF1R;IGFIR;IGFR;JTK13 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | IGF1R |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human IGF1 Receptor(1353-1367aa RKNERALPLPQSSTC),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 130KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | IGF1R(Insulin-like Growth Factor 1(IGF-1) Receptor) is a protein found on the surface of human cells.It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1(IGF-1) and by a related hormone called IGF-2.It belongs to the large class of tyrosine kinase receptors.The IGF1R gene is mapped on 15q26.3.IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues.Using a yeast 2-hybrid system,Dey et al.(1998) identified a regulatory subunit of phosphatidylinositol(PI) 3-kinase,PIK3R3,as a binding partner of IGF1R.Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells,a Drosophila cell line which lacks endogenous SP1.In these cells,BRCA1 suppressed 45% of the SP1-induced trans-activation of the IGF1R promoter.Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation.Like the insulin receptor,the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines.IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin.Part of this signaling may be via IGF1R-InsulinReceptor heterodimers. |
| Uniprot ID | P08069 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | insulin-like growth factor 1 receptor |
| 蛋白名全称 | Insulin-like growth factor 1 receptor |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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